7N8W

Crystal structure of ERI2 nuclease bound to rAMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ERI1 exoribonuclease 2	polymer	264	29951.6	2	UniProt (A8K979) Pfam (PF00929) In PDB	Homo sapiens (Human)	Exonuclease domain-containing protein 1
2	A	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	1	Chemie (AMP)
3	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	B	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
5	B	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6		water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B: 1 - 243 (UniProt: A8K979)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Ala 213	His 213	conflict
Ala 218	Asp 218	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59903.2
Non-Polymers*	Number of molecules	7
	Total formula weight	848.5
All*	Total formula weight	60751.6

*Water molecules are not included.