7N7X
Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Plasma kallikrein light chain | polymer | 236 | 26669.4 | 1 | UniProt (P03952) Pfam (PF00089) | Homo sapiens (Human) | |
| 2 | B (AAA) | Orladeyo | non-polymer | 562.6 | 1 | Chemie (0RI) | |||
| 3 | C (AAA) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (AAA) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
AAA: 1 - 313 (UniProt: P03952)
| PDB | External Database | Details |
|---|---|---|
| Glu 6 | Asn 396 | engineered mutation |
| Glu 63 | Asn 453 | engineered mutation |
| Glu 104 | Asn 494 | engineered mutation |
| Ser 113 | Cys 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26669.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 657.5 | |
| All* | Total formula weight | 27326.9 |
