7N7L

Crystal Structure of PI5P4KIIAlpha complex with BI-D1870

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	polymer	377	43114.7	1	UniProt (P48426) Pfam (PF01504) In PDB	Homo sapiens (Human)	1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha,Diphosphoinositide kinase 2-alpha,PIP5KIII,Phosphatidylinositol 5-Phosphate 4-Kinase,PI5P4Kalpha,Phosphatidylinositol 5-phosphate 4-kinase type II alpha,PI(5)P 4-kinase type II alpha,PIP4KII-alpha,PtdIns(4)P-5-kinase B isoform,PtdIns(4)P-5-kinase C isoform,PtdIns(5)P-4-kinase isoform 2-alpha
2	A	(7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one	non-polymer		391.4	1	Chemie (584)
3	A	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4		water	water		18.0	100	Chemie (HOH)

Sequence modifications

A: 33 - 405 (UniProt: P48426)

PDB	External Database	Details
Gly 29	-	expression tag
Ser 30	-	expression tag
His 31	-	expression tag
Met 32	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43114.7
Non-Polymers*	Number of molecules	4
	Total formula weight	679.6
All*	Total formula weight	43794.3

*Water molecules are not included.