7N6Q
Structure of PPPA bound human ACAT2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterol O-acyltransferase 2 | polymer | 530 | 60893.0 | 4 | UniProt (O75908) Pfam (PF03062) | Homo sapiens (Human) | Acyl-coenzyme A:cholesterol acyltransferase 2,ACAT-2,Cholesterol acyltransferase 2 |
| 2 | E, I, M, Q (A, B, C, D) | (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3,6-diyl diacetate | non-polymer | 583.6 | 4 | Chemie (7T8) | |||
| 3 | F, G, J, K, N... (A, B, C, D) | CHOLESTEROL | non-polymer | 386.7 | 8 | Chemie (CLR) | |||
| 4 | H, L, P, T (A, B, C, D) | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) |
Sequence modifications
A, B, C, D: 2 - 522 (UniProt: O75908)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
| Gly 14 | Glu 14 | variant |
| Ile 254 | Thr 254 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 243572.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 6557.6 | |
| All* | Total formula weight | 250129.6 |
