7N6N

SARS-CoV-2 Main protease C145S mutant in complex with N and C-terminal residues

Replaces:  7KVG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	3C-like proteinase	polymer	314	34567.4	2	UniProt (P0DTD1) Pfam (PF05409)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase
2	C (C)	3C-like proteinase	polymer	8	775.9	1	UniProt (P0DTD1)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase

Sequence modifications

A, B: -4 - 306 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -7	-	expression tag
Ala -6	-	expression tag
Met -5	-	expression tag
Ser 145	Cys 3408	engineered mutation

C: -4 - 0 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -7	-	expression tag
Ala -6	-	expression tag
Met -5	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	69910.7
All*	Total formula weight	69910.7

*Water molecules are not included.