7N4X
Structure of human NPC1L1 mutant-W347R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Isoform 2 of NPC1-like intracellular cholesterol transporter 1 | polymer | 1332 | 145875.0 | 1 | UniProt (Q9UHC9) Pfam (PF16414) Pfam (PF22314) Pfam (PF12349) Pfam (PF02460) In PDB | Homo sapiens (Human) | Niemann-Pick C1-like protein 1 |
| 2 | B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | A | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence modifications
A: 1 - 1332 (UniProt: Q9UHC9)
| PDB | External Database | Details |
|---|---|---|
| Arg 347 | Trp 347 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 145875.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2044.8 | |
| All* | Total formula weight | 149193.0 |
