7N2M
Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase alpha catalytic subunit | polymer | 922 | 105583.8 | 1 | UniProt (P09884) Pfam (PF03104) Pfam (PF00136) | Homo sapiens (Human) | DNA polymerase alpha catalytic subunit p180 |
| 2 | B (B) | RNA (5'-R(*GP*CP*CP*UP*GP*GP*AP*GP*CP*GP*C)-3') | polymer | 11 | 3537.2 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(*AP*T*AP*GP*TP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3') | polymer | 15 | 4570.0 | 1 | Homo sapiens | ||
| 4 | D (A) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 1 | Chemie (DCP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G, K, L (A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | H (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 8 | I (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 9 | J (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 10 | M, N, O (A, B, C) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A: 336 - 1257 (UniProt: P09884)
| PDB | External Database | Details |
|---|---|---|
| Ala 516 | Val 516 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113690.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1126.5 | |
| All* | Total formula weight | 114817.5 |
