7N1R
A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Endoplasmic reticulum chaperone BiP | polymer | 606 | 67238.0 | 2 | UniProt (P11021) Pfam (PF00012) | Homo sapiens (Human) | 78 kDa glucose-regulated protein,GRP-78,Binding-immunoglobulin protein,BiP,Heat shock protein 70 family protein 5,HSP70 family protein 5,Heat shock protein family A member 5,Immunoglobulin heavy chain-binding protein |
| 2 | C, D, E, F, T... (A, B) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 3 | AA, BA, G, H, U... (B, A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | CA, DA, EA, FA, GA... (B, A) | PHOSPHATE ION | non-polymer | 95.0 | 14 | Chemie (PO4) PubChem (1061) | |||
| 5 | P, V (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | HA, Q (B, A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 7 | S (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 8 | JA, KA (A, B) | water | water | 18.0 | 1068 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 629 (UniProt: P11021)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | - | expression tag |
| Val 453 | Thr 453 | conflict |
| Gly 454 | Ala 454 | conflict |
| Gly 455 | Ser 455 | conflict |
| - | Asp 456 | deletion |
| - | Asn 457 | deletion |
| - | Gln 458 | deletion |
| - | Pro 459 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 134476.0 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 3491.9 | |
| All* | Total formula weight | 137967.9 |
