7MYY
Crystal Structure of HIV-1 PRS17 with GRL-142
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protease | polymer | 99 | 10792.6 | 2 | UniProt (I7AJ09) Pfam (PF00077) UniProt (by SIFTS) (I7BFC3) In PDB | Human immunodeficiency virus 1 | Retropepsin |
| 2 | A | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate | non-polymer | 706.8 | 1 | Chemie (7OA) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: I7AJ09)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | conflict |
| Leu 46 | Met 46 | conflict |
| Val 48 | Gly 48 | conflict |
| Ala 67 | Cys 67 | conflict |
| Ile 77 | Val 77 | conflict |
| Ser 82 | Ala 82 | conflict |
| Leu 93 | Ile 93 | conflict |
| Ala 95 | Arg 95 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21585.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 926.5 | |
| All* | Total formula weight | 22511.8 |
