7MYU
BACE-1 in complex with compound #22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Beta-secretase 1 | polymer | 442 | 48970.1 | 2 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (Human) | Aspartyl protease 2,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 |
| 2 | A, B | N-{3-[(4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide | non-polymer | 498.5 | 2 | Chemie (ZR7) | |||
| 3 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 730 | Chemie (HOH) |
Sequence modifications
A, B: -47 - 393 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Met -48 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 97940.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1093.1 | |
| All* | Total formula weight | 99033.3 |
