7MXX
Crystal structure of human exonuclease 1 Exo1 (R92A) in complex with 5' flap DNA (uf4)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Z) | Exonuclease 1 | polymer | 352 | 39473.8 | 1 | UniProt (Q9UQ84) Pfam (PF00752) Pfam (PF00867) | Homo sapiens (human) | hExo1,Exonuclease I,hExoI |
| 2 | B (A) | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*GP*AP*C)-3') | polymer | 14 | 4255.8 | 1 | synthetic construct | ||
| 3 | C (B) | DNA (5'-D(P*TP*CP*TP*CP*GP*TP*CP*AP*CP*TP*AP*GP*CP*G)-3') | polymer | 14 | 4231.8 | 1 | synthetic construct | ||
| 4 | D, E, F, G (Z) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 5 | H (Z) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | I, J (Z, B) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
Z: 1 - 352 (UniProt: Q9UQ84)
| PDB | External Database | Details |
|---|---|---|
| Ala 92 | Arg 92 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 47961.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 259.8 | |
| All* | Total formula weight | 48221.2 |
