7MWX

Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 with tamarin CD81

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, G)	Core protein precursor eE2	polymer	259	29314.1	2	UniProt (A0A2I6PIY1) Pfam (PF01560) UniProt (by SIFTS) (A0A2I6PIY9)	Hepacivirus C	Envelope glycoprotein E1,Envelope glycoprotein E2,Genome polyprotein,Gp32,Hepacivirin,Mature core protein,NS1,NS3 helicase,NS3 protease,NS3P,NS5B,Non-structural protein 4A,Non-structural protein 4B,Non-structural protein 5A,Protease NS2,RNA-directed RNA polymerase,Serine protease/helicase NS3,Viroporin p7,Viroporin p70,gp35,gp68,gp70,p21,p23,p27,p56/58,p68,p8
2	C, F (A, E)	2A12 Fab Heavy Chain	polymer	218	23207.6	2		Mus musculus
3	D, G (B, F)	2A12 Fab Light Chain	polymer	218	24111.6	2		Mus musculus
4	E, H (D, H)	CD81 protein	polymer	93	10141.4	2	UniProt (Q9N0J9) Pfam (PF00335)	Saguinus oedipus (Cotton-top tamarin)
5	I (I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	J (J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	K, L, M (C, G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

D, H: 10 - 99 (UniProt: Q9N0J9)

PDB	External Database	Details
Thr 7	-	cloning artifact
Gly 8	-	cloning artifact
Ser 9	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	173549.4
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	175224.0

*Water molecules are not included.