7MSS

Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinate, magnesium ion and CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	polymer	315	33526.4	1	UniProt (P53597) Pfam (PF02629) Pfam (PF00549) In PDB	Homo sapiens (Human)	Succinyl-CoA synthetase subunit alpha,SCS-alpha
2	B	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	polymer	395	42627.8	1	UniProt (Q96I99) Pfam (PF08442) Pfam (PF00549) In PDB	Homo sapiens (Human)	GTP-specific succinyl-CoA synthetase subunit beta,GTPSCS,Succinyl-CoA synthetase beta-G chain,SCS-betaG
3	A	COENZYME A	non-polymer		767.5	1	Chemie (COA)
4	A, B	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
6	B	SUCCINIC ACID	non-polymer		118.1	1	Chemie (SIN)
7	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8		water	water		18.0	273	Chemie (HOH)

Sequence modifications

A: 2 - 306 (UniProt: P53597)

PDB	External Database	Details
Met 1	-	initiating methionine
Gln 105	Glu 145	engineered mutation
Glu 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag

B: 2 - 395 (UniProt: Q96I99)

PDB	External Database	Details
Met 1	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76154.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1373.3
All*	Total formula weight	77527.4

*Water molecules are not included.