7MSR

Human E105Qa GTP-specific succinyl-CoA synthetase complexed with succinyl-phosphate, magnesium ion and desulfo-coenzyme A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	polymer	315	33526.4	1	UniProt (P53597) Pfam (PF02629) Pfam (PF00549)	Homo sapiens (Human)	Succinyl-CoA synthetase subunit alpha,SCS-alpha
2	B (B)	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	polymer	395	42627.8	1	UniProt (Q96I99) Pfam (PF08442) Pfam (PF00549)	Homo sapiens (Human)	GTP-specific succinyl-CoA synthetase subunit beta,GTPSCS,Succinyl-CoA synthetase beta-G chain,SCS-betaG
3	C (A)	DESULFO-COENZYME A	non-polymer		735.5	1	Chemie (DCA)
4	D (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	E, F, H, J (A, B)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	G (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
7	I (B)	4-oxo-4-(phosphonooxy)butanoic acid	non-polymer		198.1	1	Chemie (ZNS)
8	K, L (A, B)	water	water		18.0	299	Chemie (HOH)

Sequence modifications

A: 2 - 306 (UniProt: P53597)

PDB	External Database	Details
Met 1	-	initiating methionine
Gln 105	Glu 145	engineered mutation
Glu 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag

B: 2 - 395 (UniProt: Q96I99)

PDB	External Database	Details
Met 1	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76154.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1388.3
All*	Total formula weight	77542.4

*Water molecules are not included.