7MRR

Crystal Structure of SARS-CoV-2 Main Protease (3CLpro/Mpro) in Complex with Covalent Inhibitor Leupeptin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	3C-like proteinase	polymer	306	33825.5	1	UniProt (P0DTD1) Pfam (PF05409) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase
2	B	LEUPEPTIN	polymer	4	429.6	1	BIRD (PRD_000216)	synthetic construct
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
4		water	water		18.0	38	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34255.1
Non-Polymers*	Number of molecules	4
	Total formula weight	312.5
All*	Total formula weight	34567.7

*Water molecules are not included.