7MRC
Crystal structure of the first bromodomain (BD1) of human BRDT bound to GXH-II-052
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain testis-specific protein | polymer | 113 | 13319.4 | 2 | UniProt (Q58F21) Pfam (PF00439) | Homo sapiens (Human) | Cancer/testis antigen 9,CT9,RING3-like protein |
| 2 | C, D, E, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | F (B) | N,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide} | non-polymer | 1366.4 | 1 | Chemie (ZMS) | |||
| 4 | I (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 137 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Ser 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26638.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1754.9 | |
| All* | Total formula weight | 28393.6 |
