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7MR5

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BBromodomain-containing protein 4polymer12715099.42UniProt (O60885)
Pfam (PF00439)
In PDB
Homo sapiens (Human)Protein HUNK1
2AN,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide}non-polymer1366.41Chemie (ZMS)
3A1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
4waterwater18.0161Chemie (HOH)
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight30198.8
Non-Polymers*Number of molecules3
Total formula weight1490.5
All*Total formula weight31689.3
*Water molecules are not included.

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PDB entries from 2024-06-12

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