7MQO
The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, C) | Insulin A chain | polymer | 24 | 2736.1 | 2 | UniProt (P01308) | Homo sapiens | |
| 2 | B, F (B, D) | Insulin B chain | polymer | 22 | 2538.0 | 2 | UniProt (P01308) | Homo sapiens | |
| 3 | C, D (F, E) | Isoform Short of Insulin receptor | polymer | 917 | 104761.9 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) | Homo sapiens (Human) | IR |
| 4 | G, H (G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | I, J, K, L, M... (F, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A, C: 1 - 21 (UniProt: P01308)
B, D: 1 - 22 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| His 21 | Asn 110 | engineered mutation |
| Ser 22 | - | insertion |
| Leu 23 | - | insertion |
| Gln 24 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Glu 10 | His 34 | conflict |
| Leu 20 | Gly 44 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 220071.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 223575.2 |
