7MMN
Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (L, E, G) | AM14 Fab Light Chain | polymer | 219 | 24029.7 | 3 | Homo sapiens | ||
| 2 | D, F, H (A, C, J) | Fusion glycoprotein F2 | polymer | 72 | 8173.3 | 3 | UniProt (P03420) | Human respiratory syncytial virus | |
| 3 | E, G, I (B, I, K) | Fusion glycoprotein F1,Fibritin | polymer | 414 | 45609.1 | 3 | UniProt (P03420) Pfam (PF00523) | Human respiratory syncytial virus | |
| 4 | J, K, L (M, H, D) | AM14 Fab Heavy Chain | polymer | 244 | 26380.4 | 3 | Homo sapiens | ||
| 5 | M (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | N (M) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
B, I, K: 137 - 513 (UniProt: P03420)
B, I, K: 514 - 550 (PDB: 7MMN)
| PDB | External Database | Details |
|---|---|---|
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Val 379 | Ile 379 | variant |
| Val 447 | Met 447 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 312577.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 313.3 | |
| All* | Total formula weight | 312890.9 |
