7MMN
Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | L, E, G | AM14 Fab Light Chain | polymer | 219 | 24029.7 | 3 | Homo sapiens | ||
2 | A, C, J | Fusion glycoprotein F2 | polymer | 72 | 8173.3 | 3 | UniProt (P03420) In PDB | Human respiratory syncytial virus | |
3 | B, I, K | Fusion glycoprotein F1,Fibritin | polymer | 414 | 45609.1 | 3 | UniProt (P03420) Pfam (PF00523) In PDB | Human respiratory syncytial virus | |
4 | M, H, D | AM14 Fab Heavy Chain | polymer | 244 | 26380.4 | 3 | Homo sapiens | ||
5 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
6 | M | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
B, I, K: 137 - 513 (UniProt: P03420)
B, I, K: 514 - 550 (PDB: 7MMN)
PDB | External Database | Details |
---|---|---|
Cys 155 | Ser 155 | engineered mutation |
Phe 190 | Ser 190 | engineered mutation |
Leu 207 | Val 207 | engineered mutation |
Cys 290 | Ser 290 | engineered mutation |
Val 379 | Ile 379 | variant |
Val 447 | Met 447 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 312577.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 313.3 | |
All* | Total formula weight | 312890.9 |