7MLK
Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 968 | 112619.9 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PI3-kinase subunit alpha,PI3K-alpha,PI3Kalpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,p110alpha,Phosphoinositide 3-kinase alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
2 | A | 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide | non-polymer | 380.4 | 1 | Chemie (ZHY) |
Sequence modifications
A: 105 - 1048 (UniProt: P42336)
PDB | External Database | Details |
---|---|---|
Met 81 | - | initiating methionine |
Ala 82 | - | expression tag |
Ser 83 | - | expression tag |
His 84 | - | expression tag |
His 85 | - | expression tag |
His 86 | - | expression tag |
His 87 | - | expression tag |
His 88 | - | expression tag |
His 89 | - | expression tag |
Asp 90 | - | expression tag |
Tyr 91 | - | expression tag |
Asp 92 | - | expression tag |
Gly 93 | - | expression tag |
Ala 94 | - | expression tag |
Thr 95 | - | expression tag |
Thr 96 | - | expression tag |
Glu 97 | - | expression tag |
Asn 98 | - | expression tag |
Leu 99 | - | expression tag |
Tyr 100 | - | expression tag |
Phe 101 | - | expression tag |
Gln 102 | - | expression tag |
Gly 103 | - | expression tag |
Ser 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 112619.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 380.4 | |
All* | Total formula weight | 113000.3 |