7MHC
Structure of human STING in complex with MK-1454
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stimulator of interferon genes protein | polymer | 188 | 21555.2 | 1 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (Human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | B (A) | (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione | non-polymer | 708.5 | 1 | Chemie (ZEV) | |||
| 3 | C (A) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 154 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ala 230 | Gly 230 | engineered mutation |
| Arg 232 | His 232 | engineered mutation |
| Gln 293 | Arg 293 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21555.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 708.5 | |
| All* | Total formula weight | 22263.7 |
