7MF0

Co-crystal structure of PERK with inhibitor (R)-2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (AAA)	Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3	polymer	317	36816.4	1	UniProt (Q9NZJ5) Pfam (PF00069)	Homo sapiens (Human)	PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK,PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK
2	B (AAA)	2-amino-N-cyclopropyl-5-(4-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}-2-methylphenyl)pyridine-3-carboxamide	non-polymer		452.5	1	Chemie (Z6P)

Sequence modifications

AAA: 575 - 872 (UniProt: Q9NZJ5)

PDB	External Database	Details
Gly 573	-	expression tag
Ser 574	-	expression tag

AAA: 873 - 1094 (UniProt: Q9NZJ5)

PDB	External Database	Details
Asn 937	Asp 937	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36816.4
Non-Polymers*	Number of molecules	1
	Total formula weight	452.5
All*	Total formula weight	37268.8

*Water molecules are not included.