7MDU
BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H | Rh.33104 mAb.1 Heavy Chain | polymer | 116 | 12421.8 | 1 | Macaca mulatta | ||
| 2 | A | Surface protein gp120 | polymer | 513 | 57652.6 | 1 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | SU, Glycoprotein 120, gp120 |
| 3 | E | RM20A3 mAb Heavy Chain | polymer | 125 | 13511.1 | 1 | Macaca mulatta | ||
| 4 | F | RM20A3 mAb Light Chain | polymer | 111 | 11755.8 | 1 | Macaca mulatta | ||
| 5 | L | Rh.33104 mAb.1 Light Chain | polymer | 106 | 11521.6 | 1 | Macaca mulatta | ||
| 6 | B | Transmembrane protein gp41 | polymer | 153 | 17134.3 | 1 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | TM, Glycoprotein 41, gp41 |
| 7 | C, D, G, J, K... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
| 8 | I | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | B, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) |
Sequence modifications
A: 31 - 511 (UniProt: Q2N0S6)
B: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Lys 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Val 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Val 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 21 | - | expression tag |
| His 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Glu 106 | Thr 105 | conflict |
| Ile 271 | Met 270 | conflict |
| Leu 288 | Phe 287 | conflict |
| Val 304 | Arg 303 | conflict |
| Tyr 319 | Ala 316 | conflict |
| Asn 332 | Thr 330 | conflict |
| Gln 363 | Asn 361 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | Glu 506 | conflict |
| Arg 510 | Lys 507 | conflict |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Phe 516 | conflict |
| Pro 559 | Ile 556 | conflict |
| Pro 561 | Ala 558 | conflict |
| Asp 568 | Leu 565 | conflict |
| His 570 | Val 567 | conflict |
| His 585 | Arg 582 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 123997.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 4306.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2654.5 | |
| All* | Total formula weight | 130957.7 |
