7MDP
KRas G12C in complex with G-2897
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 169 | 19317.8 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (H) | IgG heavy chain | polymer | 226 | 23833.6 | 1 | Homo sapiens | ||
| 3 | C (I) | IgG light chain | polymer | 215 | 22878.3 | 1 | Homo sapiens | ||
| 4 | D (A) | 4-(trifluoromethyl)-1,3-benzothiazol-2-amine | non-polymer | 218.2 | 1 | Chemie (Z07) | |||
| 5 | E (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 6 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | G, N (A, H) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 8 | H, I, J, S (H, I) | CACODYLIC ACID | non-polymer | 138.0 | 4 | Chemie (CAD) | |||
| 9 | K, M, O, U (H, I) | 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | non-polymer | 296.4 | 4 | Chemie (P15) | |||
| 10 | L, P, Q, R (H, I) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 11 | T (I) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 12 | V, W, X (A, H, I) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66029.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2867.6 | |
| All* | Total formula weight | 68897.3 |
