7MD4
Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | N, M | Isoform Short of Insulin receptor subunit alpha | polymer | 30 | 3459.8 | 2 | UniProt (P06213) In PDB | Homo sapiens (Human) | IR |
2 | B, A | Isoform Short of Insulin receptor | polymer | 927 | 106143.4 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870) In PDB | Homo sapiens (Human) | IR |
3 | U, S, Q, O | Insulin chain A | polymer | 21 | 2383.7 | 4 | UniProt (P01308) In PDB | Homo sapiens (Human) | |
4 | V, T, R, P | Insulin B chain | polymer | 30 | 3434.0 | 4 | UniProt (P01308) Pfam (PF00049) In PDB | Homo sapiens (Human) |
Sequence modifications
N, M: 694 - 720 (UniProt: P06213)
B, A: 1 - 917 (UniProt: P06213)
PDB | External Database | Details |
---|---|---|
Ala 691 | - | expression tag |
Ala 692 | - | expression tag |
Ala 693 | - | expression tag |
Ser 717 | Arg 744 | conflict |
PDB | External Database | Details |
---|---|---|
His 918 | - | expression tag |
His 919 | - | expression tag |
His 920 | - | expression tag |
His 921 | - | expression tag |
His 922 | - | expression tag |
His 923 | - | expression tag |
His 924 | - | expression tag |
His 925 | - | expression tag |
His 926 | - | expression tag |
His 927 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 242477.0 | |
All* | Total formula weight | 242477.0 |