7MD4

Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (N, M)	Isoform Short of Insulin receptor subunit alpha	polymer	30	3459.8	2	UniProt (P06213)	Homo sapiens (Human)	IR
2	C, D (B, A)	Isoform Short of Insulin receptor	polymer	927	106143.4	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870)	Homo sapiens (Human)	IR
3	E, G, I, J (U, S, Q, O)	Insulin chain A	polymer	21	2383.7	4	UniProt (P01308)	Homo sapiens (Human)
4	F, H, K, L (V, T, R, P)	Insulin B chain	polymer	30	3434.0	4	UniProt (P01308) Pfam (PF00049)	Homo sapiens (Human)

Sequence modifications

N, M: 694 - 720 (UniProt: P06213)

PDB	External Database	Details
Ala 691	-	expression tag
Ala 692	-	expression tag
Ala 693	-	expression tag
Ser 717	Arg 744	conflict

B, A: 1 - 917 (UniProt: P06213)

PDB	External Database	Details
His 918	-	expression tag
His 919	-	expression tag
His 920	-	expression tag
His 921	-	expression tag
His 922	-	expression tag
His 923	-	expression tag
His 924	-	expression tag
His 925	-	expression tag
His 926	-	expression tag
His 927	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	242477.0
All*	Total formula weight	242477.0

*Water molecules are not included.