7MBU
Cryo-EM structure of zebrafish TRPM5 E337A mutant in the presence of 5 mM calcium (high calcium occupancy in the transmembrane domain)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential melastatin 5 | polymer | 1165 | 132741.0 | 4 | UniProt (S5UH55) Pfam (PF18139) Pfam (PF00520) | Danio rerio (Zebrafish Brachydanio rerio) | |
| 2 | E, J, N, R (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 3 | F, K, O, S (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | G, I, M, Q (A, B, C) | (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside | non-polymer | 841.0 | 4 | Chemie (YUY) | |||
| 5 | H, L, P, T (A, B, C, D) | (25R)-14beta,17beta-spirost-5-en-3beta-ol | non-polymer | 414.6 | 4 | Chemie (YUV) |
Sequence modifications
A, B, C, D: 1 - 1165 (UniProt: S5UH55)
| PDB | External Database | Details |
|---|---|---|
| Ala 337 | Glu 337 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 530963.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 6067.8 | |
| All* | Total formula weight | 537031.6 |
