7MAS
Drug Resistant HIV-1 Protease (L10F, M46I, I50V, F53L, L63P, G73S) in Complex with DRV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, D, C, A | Protease | polymer | 99 | 10813.8 | 4 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 group M subtype B (HIV-1) | PR,Retropepsin |
| 2 | C, A | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 2 | Chemie (017) | |||
| 3 | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
B, D, C, A: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | conflict |
| Phe 10 | Leu 510 | engineered mutation |
| Asn 37 | Ser 537 | conflict |
| Ile 46 | Met 546 | engineered mutation |
| Val 50 | Ile 550 | engineered mutation |
| Leu 53 | Phe 553 | engineered mutation |
| Pro 63 | Leu 563 | engineered mutation |
| Ser 73 | Gly 573 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43255.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1095.3 | |
| All* | Total formula weight | 44350.3 |
