7MAQ

Drug Resistant HIV-1 Protease (L10F, V32I, L33F, K45I, A71V, V82I, I84V) in Complex with DRV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Protease	polymer	99	10925.9	2	UniProt (P03367) Pfam (PF00077) In PDB	Human immunodeficiency virus type 1 group M subtype B (HIV-1)	PR,Retropepsin
2	B	(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE	non-polymer		547.7	1	Chemie (017)
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4		water	water		18.0	121	Chemie (HOH)

Sequence modifications

B, A: 1 - 99 (UniProt: P03367)

PDB	External Database	Details
Lys 7	Gln 507	conflict
Phe 10	Leu 510	engineered mutation
Ile 32	Val 532	engineered mutation
Phe 33	Leu 533	engineered mutation
Asn 37	Ser 537	conflict
Ile 45	Lys 545	engineered mutation
Val 71	Ala 571	engineered mutation
Ile 82	Val 582	engineered mutation
Val 84	Ile 584	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21851.8
Non-Polymers*	Number of molecules	2
	Total formula weight	643.7
All*	Total formula weight	22495.6

*Water molecules are not included.