7MAP
Drug Resistant HIV-1 Protease (L10I, V32I, L33F, K45I, M46I, I50V, A71V, V82I, I84V) in Complex with DRV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protease | polymer | 99 | 10859.8 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus type 1 group M subtype B (HIV-1) | PR,Retropepsin |
| 2 | A | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 1 | Chemie (017) | |||
| 3 | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | conflict |
| Ile 10 | Leu 510 | engineered mutation |
| Ile 32 | Val 532 | engineered mutation |
| Phe 33 | Leu 533 | engineered mutation |
| Asn 37 | Ser 537 | conflict |
| Ile 45 | Lys 545 | engineered mutation |
| Ile 46 | Met 546 | engineered mutation |
| Val 50 | Ile 550 | engineered mutation |
| Val 71 | Ala 571 | engineered mutation |
| Ile 82 | Val 582 | engineered mutation |
| Val 84 | Ile 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21719.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 547.7 | |
| All* | Total formula weight | 22267.4 |
