7M7W

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (B, L)	Monoclonal antibody S2X259 Fab light chain	polymer	219	22993.3	2		Homo sapiens (Human)
2	B, F (A, H)	Monoclonal antibody S2X259 Fab heavy chain	polymer	229	24351.4	2		Homo sapiens (Human)
3	C, G (D, F)	Monoclonal antibody S2H97 Fab light chain	polymer	218	22935.2	2		Homo sapiens (Human)
4	D, H (C, E)	Monoclonal antibody S2H97 Fab heavy chain	polymer	223	24174.1	2		Homo sapiens (Human)
5	I, J (S, R)	Spike protein S1	polymer	216	24442.3	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
6	K, L (S, R)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	M, N, O, P, Q... (B, A, D, C, L...)	water	water		18.0	95	Chemie (HOH)

Sequence modifications

S, R: 328 - 531 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
Thr 327	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	237792.8
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	238235.2

*Water molecules are not included.