7M7D
Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with IACS-8968
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Indoleamine 2,3-dioxygenase 1 | polymer | 411 | 46295.3 | 2 | UniProt (P14902) Pfam (PF01231) In PDB | Homo sapiens (Human) | IDO-1,Indoleamine-pyrrole 2,3-dioxygenase |
2 | A, B | (5S)-6,6-dimethyl-8-[(4S)-7-(trifluoromethyl)imidazo[1,5-a]pyridin-5-yl]-1,3,8-triazaspiro[4.5]decane-2,4-dione | non-polymer | 381.4 | 2 | Chemie (YRM) | |||
3 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
4 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 11 - 403 (UniProt: P14902)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Ser 0 | - | expression tag |
Ser 1 | - | expression tag |
Gly 2 | - | expression tag |
Leu 3 | - | expression tag |
Val 4 | - | expression tag |
Pro 5 | - | expression tag |
Arg 6 | - | expression tag |
Gly 7 | - | expression tag |
Ser 8 | - | expression tag |
His 9 | - | expression tag |
Met 10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 92590.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1995.7 | |
All* | Total formula weight | 94586.2 |