7M5Z

Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase Mer	polymer	313	36001.5	2	UniProt (Q12866) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK
2	C, D (A, B)	2-(butylamino)-N-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide	non-polymer		450.6	2	Chemie (YR7)
3	E, F (A, B)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A, B: 570 - 864 (UniProt: Q12866)

PDB	External Database	Details
Met 552	-	initiating methionine
Gly 553	-	expression tag
Ser 554	-	expression tag
Ser 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag
Ser 562	-	expression tag
Ser 563	-	expression tag
Gly 564	-	expression tag
Leu 565	-	expression tag
Val 566	-	expression tag
Pro 567	-	expression tag
Arg 568	-	expression tag
Gly 569	-	expression tag
Arg 591	Lys 591	conflict
Arg 693	Lys 693	conflict
Arg 702	Lys 702	conflict
Arg 856	Lys 856	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72003.0
Non-Polymers*	Number of molecules	2
	Total formula weight	901.2
All*	Total formula weight	72904.2

*Water molecules are not included.