7M5Z
Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase Mer | polymer | 313 | 36001.5 | 2 | UniProt (Q12866) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK |
2 | A, B | 2-(butylamino)-N-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide | non-polymer | 450.6 | 2 | Chemie (YR7) | |||
3 | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B: 570 - 864 (UniProt: Q12866)
PDB | External Database | Details |
---|---|---|
Met 552 | - | initiating methionine |
Gly 553 | - | expression tag |
Ser 554 | - | expression tag |
Ser 555 | - | expression tag |
His 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
Ser 562 | - | expression tag |
Ser 563 | - | expression tag |
Gly 564 | - | expression tag |
Leu 565 | - | expression tag |
Val 566 | - | expression tag |
Pro 567 | - | expression tag |
Arg 568 | - | expression tag |
Gly 569 | - | expression tag |
Arg 591 | Lys 591 | conflict |
Arg 693 | Lys 693 | conflict |
Arg 702 | Lys 702 | conflict |
Arg 856 | Lys 856 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72003.0 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 901.2 | |
All* | Total formula weight | 72904.2 |