7M5W

Crystal structure of the HMG-C1 domain of human capicua bound to DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein capicua homolog	polymer	186	21962.2	1	UniProt (Q96RK0)	Homo sapiens (Human)
2	B (B)	DNA (5'-D(*GP*GP*TP*TP*AP*TP*GP*AP*AP*TP*GP*AP*AP*AP*AP*AP*GP*C)-3')	polymer	18	5612.7	1		synthetic construct
3	C (C)	DNA (5'-D(*GP*CP*TP*TP*TP*TP*TP*CP*AP*TP*TP*CP*AP*TP*AP*AP*CP*C)-3')	polymer	18	5416.5	1		synthetic construct
4	D (B)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	E, F, G (A, B, C)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 22 - 114 (UniProt: Q96RK0)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Ser 12	-	expression tag
Gly 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Pro 16	-	expression tag
Arg 17	-	expression tag
Gly 18	-	expression tag
Ser 19	-	expression tag
His 20	-	expression tag
Met 21	-	expression tag

A: 116 - 186 (UniProt: Q96RK0)

PDB	External Database	Details
Phe 115	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	32991.4
Non-Polymers*	Number of molecules	1
	Total formula weight	40.1
All*	Total formula weight	33031.5

*Water molecules are not included.