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7M3S

The internal aldimine form of the wild-type Salmonella Typhimurium Tryptophan Synthase in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor at the alpha-and beta-site, sodium ion at the metal coordination site, and another F6F molecule at the enzyme beta-site at 1.55 Angstrom resolution. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ATryptophan synthase alpha chainpolymer26828698.81UniProt (P00929)
Pfam (PF00290)
In PDB
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
2BTryptophan synthase beta chainpolymer39742918.91UniProt (P0A2K1)
Pfam (PF00291)
In PDB
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
3A, B2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATEnon-polymer329.22Chemie (F6F)
4A, B1,2-ETHANEDIOLnon-polymer62.17Chemie (EDO)
5A, BCHLORIDE IONnon-polymer35.52Chemie (CL)
6BPYRIDOXAL-5'-PHOSPHATEnon-polymer247.11Chemie (PLP)
7BDI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
8BDIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
9BSODIUM IONnon-polymer23.02Chemie (NA)
10waterwater18.0550Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight71617.7
Non-Polymers*Number of molecules16
Total formula weight1641.1
All*Total formula weight73258.8
*Water molecules are not included.

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PDB entries from 2024-07-24

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