7M3F
Asymmetric Activation of the Calcium Sensing Receptor Homodimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Extracellular calcium-sensing receptor | polymer | 902 | 101745.4 | 2 | UniProt (P41180) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB | Homo sapiens (Human) | CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1 |
2 | C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
4 | A, B | N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine | non-polymer | 357.4 | 2 | Chemie (YP4) | |||
5 | A, B | TRYPTOPHAN | non-polymer | 204.2 | 2 | Chemie (TRP) | |||
6 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
7 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) |
Sequence modifications
A, B: 20 - 894 (UniProt: P41180)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Lys -6 | - | expression tag |
Thr -5 | - | expression tag |
Ile -4 | - | expression tag |
Ile -3 | - | expression tag |
Ala -2 | - | expression tag |
Leu -1 | - | expression tag |
Ser 0 | - | expression tag |
Tyr 1 | - | expression tag |
Ile 2 | - | expression tag |
Phe 3 | - | expression tag |
Cys 4 | - | expression tag |
Leu 5 | - | expression tag |
Val 6 | - | expression tag |
Phe 7 | - | expression tag |
Ala 8 | - | expression tag |
Asp 9 | - | expression tag |
Tyr 10 | - | expression tag |
Lys 11 | - | expression tag |
Asp 12 | - | expression tag |
Asp 13 | - | expression tag |
Asp 14 | - | expression tag |
Asp 15 | - | expression tag |
Lys 16 | - | expression tag |
Ala 17 | - | expression tag |
Ala 18 | - | expression tag |
Ala 19 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 203490.9 | |
Branched | Number of molecules | 3 |
Total formula weight | 1273.2 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 3464.4 | |
All* | Total formula weight | 208228.5 |