Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 283 | 32098.1 | 1 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B (B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 397 | 43790.3 | 1 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 3 | C, F (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H (B) | N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | non-polymer | 482.2 | 1 | Chemie (4BM) | |||
| 7 | I, J (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | K, L (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 9 | M, N (A, B) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: 445 - 723 (UniProt: P15056)
B: 1 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Gly 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Arg 444 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Ala 218 | Ser 218 | engineered mutation |
| Ala 222 | Ser 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75888.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1955.0 | |
| All* | Total formula weight | 77843.3 |
