7LYA

Cryo-EM structure of the human nucleosome core particle with linked histone proteins H2A and H2B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.1	polymer	140	15786.5	2	UniProt (P68431) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2	B, F	Histone H4	polymer	107	11743.8	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (Human)
3	D, H	Histone H2B type 1-J	polymer	126	13930.2	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H2B.1,Histone H2B.r,H2B/r
4	I	DNA (147-MER)	polymer	147	45138.8	1		Homo sapiens (Human)
5	J	DNA (146-MER)	polymer	147	45610.0	1		Homo sapiens (Human)
6	C, G	Histone H2A type 1-B/E	polymer	119	13034.2	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (Human)	Histone H2A.2,Histone H2A/a,Histone H2A/m

Sequence modifications

A, E: 0 - 135 (UniProt: P68431)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
His -1	-	expression tag

B, F: 0 - 102 (UniProt: P62805)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Gly -2	-	expression tag
His -1	-	expression tag

D, H: 0 - 123 (UniProt: P06899)

PDB	External Database	Details
Gly -2	-	expression tag
His -1	-	expression tag

C, G: 12 - 129 (UniProt: P04908)

PDB	External Database	Details
Ser 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	199738.2
All*	Total formula weight	199738.2

*Water molecules are not included.