7LWG
Crystal structure of the BCL6 BTB domain in complex with OICR-12694
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | B-cell lymphoma 6 protein | polymer | 125 | 14415.7 | 2 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | A, B | 5-{(5S)-1-[2-({3-chloro-6-[(2S)-2,4-dimethylpiperazin-1-yl]-2-fluoropyridin-4-yl}amino)-2-oxoethyl]-4-oxo-4,6,7,8-tetrahydro-1H-dipyrrolo[1,2-a:2',3'-d]pyrimidin-3-yl}-3,4-difluoro-2-hydroxybenzamide | non-polymer | 645.0 | 2 | Chemie (YN7) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A, B | UNKNOWN ATOM OR ION | non-polymer | 18.0 | 4 | Chemie (UNX) | |||
| 5 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28831.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1546.3 | |
| All* | Total formula weight | 30377.7 |
