7LWE
Crystal structure of the BCL6 BTB domain in complex with OICR-7629
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | B-cell lymphoma 6 protein | polymer | 129 | 14802.2 | 1 | UniProt (P41182) Pfam (PF00651) In PDB | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | A | N-(3-chloropyridin-4-yl)-2-(3-methyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide | non-polymer | 317.7 | 1 | Chemie (YND) | |||
| 3 | A | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 4 | A | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 1 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14802.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 517.3 | |
| All* | Total formula weight | 15319.5 |
