7LVH
CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 ISOFORM 1 COMPLEXED WITH LIGAND N-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]-3-(PROPAN-2-YL)PIPERIDINE-2-CARBOXAMIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | AP2-associated protein kinase 1 | polymer | 318 | 35978.2 | 2 | UniProt (Q3UHJ0) Pfam (PF00069) | Mus musculus (Mouse) | Adaptor-associated kinase 1 |
| 2 | C (A) | N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-D-leucinamide | non-polymer | 303.4 | 1 | Chemie (YFS) | |||
| 3 | D, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (B) | 5-[(4-aminopiperidin-1-yl)methyl]-N-{3-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]phenyl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | non-polymer | 448.6 | 1 | Chemie (YFV) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 330 (UniProt: Q3UHJ0)
| PDB | External Database | Details |
|---|---|---|
| Met 13 | - | initiating methionine |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Val 21 | - | expression tag |
| Pro 22 | - | expression tag |
| Arg 23 | - | expression tag |
| Gly 24 | - | expression tag |
| Ser 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71956.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 944.1 | |
| All* | Total formula weight | 72900.5 |
