7LU9
Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | k, j, r | DH851.3 light chain | polymer | 210 | 22127.5 | 3 | Macaca mulatta (Rhesus monkey) | ||
| 2 | l, i, q | DH851.3 heavy chain | polymer | 228 | 24451.6 | 3 | Macaca mulatta (Rhesus monkey) | ||
| 3 | m, h, p | DH851.3 heavy chain | polymer | 222 | 23890.9 | 3 | Macaca mulatta (Rhesus monkey) | ||
| 4 | n, g, o | DH851.3 light chain | polymer | 207 | 21824.1 | 3 | Macaca mulatta (Rhesus monkey) | ||
| 5 | a, b, c | Envelope glycoprotein gp41 | polymer | 153 | 17134.5 | 3 | Pfam (PF00517) UniProt (by SIFTS) (A0A6H1VGF9) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
| 6 | d, e, f | Envelope glycoprotein gp120 | polymer | 461 | 51898.1 | 3 | UniProt (M4M097) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 (HIV-1) | CH505 gp120 |
| 7 | L, O, S, A, E... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
| 8 | I, M, P, T, B... | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 6 | In PDB GlyTouCan (G22768VO) | |||
| 9 | J, Q, C | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 3 | In PDB GlyTouCan (G89445RP) | |||
| 10 | K, R, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 789.7 | 3 | In PDB GlyTouCan (G95663PY) | |||
| 11 | N, U, G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 12 | a, b, c | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
d, e, f: 35 - 505 (UniProt: M4M097)
| PDB | External Database | Details |
|---|---|---|
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Leu 34 | - | expression tag |
| Trp 316 | Ala 301 | conflict |
| Lys 490 | Glu 473 | conflict |
| Ile 491 | Val 474 | conflict |
| Glu 492 | Lys 475 | conflict |
| Arg 500 | Asn 483 | conflict |
| Cys 501 | Ala 484 | conflict |
| Lys 502 | Arg 485 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 483980.1 | |
| Branched | Number of molecules | 21 |
| Total formula weight | 15968.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 500612.4 |
