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7LRY

Structure of HIV-1 Reverse Transcriptase in complex with DNA, (-)FTC-TP, and CA(2+) ion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Reverse transcriptase p66polymer55563874.12UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Pfam (PF00075)
Human immunodeficiency virus type 1 (HIV-1)
2B, D
(B, D)
Reverse transcriptase p51polymer42950096.52UniProt (P03366)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Human immunodeficiency virus type 1 (HIV-1)
3E, F
(F, E)
DNA/RNA (38-MER)polymer3811764.52synthetic construct
4G, H
(M, N)
beta-D-fructofuranose-(2-1)-alpha-D-glucopyranosebranched342.32In PDB
5I, T, V
(A, B, C)
SULFATE IONnon-polymer96.13Chemie (SO4)
6AA, BA, CA, DA, J...
(D, F, A, B)
GLYCEROLnon-polymer92.112Chemie (GOL)
7K
(A)
TETRAETHYLENE GLYCOLnon-polymer194.21Chemie (PG4)
8L, W
(A, C)
AMMONIUM IONnon-polymer18.02Chemie (NH4)
9M, X
(A, C)
CALCIUM IONnon-polymer40.12Chemie (CA)
10N, Y
(A, C)
[[(2R,5S)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphatenon-polymer487.22Chemie (1RY)
11EA, FA, GA, HA, IA...
(A, B, C, D, F...)
waterwater18.0301Chemie (HOH)
Sequence modifications
A, C: 1 - 555 (UniProt: P03366)
PDBExternal DatabaseDetails
Ser 280Cys 879engineered mutation
Asn 498Asp 1097engineered mutation
B, D: 1 - 428 (UniProt: P03366)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ser 280Cys 879engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight251470.4
BranchedNumber of molecules2
Total formula weight684.6
Non-Polymers*Number of molecules22
Total formula weight2678.1
All*Total formula weight254833.1
*Water molecules are not included.

238268

PDB entries from 2025-07-02

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