7LRY
Structure of HIV-1 Reverse Transcriptase in complex with DNA, (-)FTC-TP, and CA(2+) ion
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C (A, C) | Reverse transcriptase p66 | polymer | 555 | 63874.1 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 (HIV-1) | |
2 | B, D (B, D) | Reverse transcriptase p51 | polymer | 429 | 50096.5 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 (HIV-1) | |
3 | E, F (F, E) | DNA/RNA (38-MER) | polymer | 38 | 11764.5 | 2 | synthetic construct | ||
4 | G, H (M, N) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB | |||
5 | I, T, V (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
6 | AA, BA, CA, DA, J... (D, F, A, B) | GLYCEROL | non-polymer | 92.1 | 12 | Chemie (GOL) | |||
7 | K (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
8 | L, W (A, C) | AMMONIUM ION | non-polymer | 18.0 | 2 | Chemie (NH4) | |||
9 | M, X (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
10 | N, Y (A, C) | [[(2R,5S)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 487.2 | 2 | Chemie (1RY) | |||
11 | EA, FA, GA, HA, IA... (A, B, C, D, F...) | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 879 | engineered mutation |
Asn 498 | Asp 1097 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 251470.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 684.6 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 2678.1 | |
All* | Total formula weight | 254833.1 |