7LRX

Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dCTP, and CA(2+) ion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Reverse transcriptase p66	polymer	555	63874.1	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 (HIV-1)
2	B, D (B, D)	Reverse transcriptase p51	polymer	429	50096.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 (HIV-1)
3	E, F (F, E)	DNA/RNA (38-MER)	polymer	38	11764.5	2		synthetic construct
4	G, H (H, L)	beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose	branched		342.3	2	In PDB
5	I, N (A, C)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	J, O (A, C)	4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one	non-polymer		467.2	2	Chemie (1S0)
7	K, P (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
8	L, Q (A, C)	AMMONIUM ION	non-polymer		18.0	2	Chemie (NH4)
9	M, R (B, D)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
10	S, T, U, V, W... (A, B, C, D, F...)	water	water		18.0	130	Chemie (HOH)

Sequence modifications

A, C: 1 - 555 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	engineered mutation
Asn 498	Asp 1097	engineered mutation

B, D: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	251470.4
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	10
	Total formula weight	1426.9
All*	Total formula weight	253581.8

*Water molecules are not included.