7LRK
Crystal structure of BPTF bromodomain in complex with inhibitor Pdy-3-093
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nucleosome-remodeling factor subunit BPTF | polymer | 123 | 14455.4 | 2 | UniProt (Q12830) Pfam (PF00439) In PDB | Homo sapiens (Human) | Bromodomain and PHD finger-containing transcription factor,Fetal Alz-50 clone 1 protein,Fetal Alzheimer antigen |
| 2 | A, B | 4-chloranyl-2-methyl-5-[[(3~{S})-pyrrolidin-3-yl]amino]pyridazin-3-one | non-polymer | 228.7 | 2 | Chemie (YC4) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B: 2917 - 3037 (UniProt: Q12830)
| PDB | External Database | Details |
|---|---|---|
| Ser 2915 | - | expression tag |
| Met 2916 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28910.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1202.2 | |
| All* | Total formula weight | 30113.0 |
