7LRI

Structure of HIV-1 Reverse Transcriptase in complex with DNA, dTTP, and CA(2+) ion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Reverse transcriptase p66	polymer	555	63874.1	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 (HIV-1)
2	B, D (B, D)	Reverse transcriptase p51	polymer	429	50096.5	2	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 (HIV-1)
3	E, F (E, F)	DNA/RNA (38-MER)	polymer	35	10817.9	2		synthetic construct
4	G, P (A, C)	THYMIDINE-5'-TRIPHOSPHATE	non-polymer		482.2	2	Chemie (TTP)
5	H, O (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6	I, J, L, M, N (A, B)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
7	K, Q (A, C)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
8	R, S, T, U, V... (A, B, C, D, E...)	water	water		18.0	97	Chemie (HOH)

Sequence modifications

A, C: 1 - 555 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 879	engineered mutation
Asn 498	Asp 1097	engineered mutation

B, D: 1 - 428 (UniProt: P03366)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	249577.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1697.1
All*	Total formula weight	251274.3

*Water molecules are not included.