7LQD
Structure of Human MPS1 (TTK) covalently bound to RMS-07 inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dual specificity protein kinase TTK or monopolar spindle 1 kinase | polymer | 313 | 36115.3 | 1 | UniProt (P33981-2) Pfam (PF00069) UniProt (by SIFTS) (P33981) In PDB | Homo sapiens (Human) | Phosphotyrosine picked threonine-protein kinase,PYT |
2 | A | ~{N}-(2,6-diethylphenyl)-2-[[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide | non-polymer | 606.8 | 1 | Chemie (YB4) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
4 | A | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL | non-polymer | 164.2 | 1 | Chemie (TOE) | |||
5 | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A: 519 - 808 (UniProt: P33981-2)
PDB | External Database | Details |
---|---|---|
Met 496 | - | expression tag |
His 497 | - | expression tag |
His 498 | - | expression tag |
His 499 | - | expression tag |
His 500 | - | expression tag |
His 501 | - | expression tag |
His 502 | - | expression tag |
Ser 503 | - | expression tag |
Ser 504 | - | expression tag |
Gly 505 | - | expression tag |
Val 506 | - | expression tag |
Asp 507 | - | expression tag |
Leu 508 | - | expression tag |
Gly 509 | - | expression tag |
Thr 510 | - | expression tag |
Glu 511 | - | expression tag |
Asn 512 | - | expression tag |
Leu 513 | - | expression tag |
Tyr 514 | - | expression tag |
Phe 515 | - | expression tag |
Gln 516 | - | expression tag |
Ser 517 | - | expression tag |
Met 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36115.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1231.4 | |
All* | Total formula weight | 37346.7 |