7LPN
Cryo-EM structure of llama J3 VHH antibody in complex with HIV-1 Env BG505 DS-SOSIP.664
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A, E | HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
2 | G, C, F | Envelope glycoprotein gp160 | polymer | 476 | 53300.3 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | Env polyprotein |
3 | H, D, I | J3 VHH | polymer | 130 | 14489.2 | 3 | Lama glama | ||
4 | b, c, J, K, S... | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
5 | d, e, g, h, i... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 15 | In PDB GlyTouCan (G42666HT) | |||
6 | f, N, W | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
7 | a, j, R | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
8 | C, E, F, B, G... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 33 | Chemie (NAG) |
Sequence modifications
B, A, E: 512 - 664 (UniProt: Q2N0S6)
G, C, F: 31 - 508 (UniProt: Q2N0S6)
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | engineered mutation |
Cys 605 | Thr 602 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Cys 201 | Ile 200 | engineered mutation |
Asn 332 | Thr 330 | engineered mutation |
Cys 433 | Ala 430 | engineered mutation |
Cys 501 | Ala 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 254808.0 | |
Branched | Number of molecules | 27 |
Total formula weight | 14377.4 | |
Non-Polymers* | Number of molecules | 33 |
Total formula weight | 7299.9 | |
All* | Total formula weight | 276485.3 |