7LPD
Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 1 | polymer | 868 | 98719.8 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) In PDB | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
2 | D, A, B, C | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 8 | Chemie (LBN) | |||
3 | D, A, B, C | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 12 | Chemie (6OU) | |||
4 | A, B, C, D | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide | non-polymer | 305.4 | 4 | Chemie (4DY) |
Sequence modifications
A, B, C, D: 1 - 838 (UniProt: O35433)
PDB | External Database | Details |
---|---|---|
Glu 839 | - | expression tag |
Asn 840 | - | expression tag |
Ser 841 | - | expression tag |
Leu 842 | - | expression tag |
Glu 843 | - | expression tag |
Val 844 | - | expression tag |
Leu 845 | - | expression tag |
Phe 846 | - | expression tag |
Gln 847 | - | expression tag |
Gly 848 | - | expression tag |
Pro 849 | - | expression tag |
Asp 850 | - | expression tag |
Tyr 851 | - | expression tag |
Lys 852 | - | expression tag |
Asp 853 | - | expression tag |
Asp 854 | - | expression tag |
Asp 855 | - | expression tag |
Asp 856 | - | expression tag |
Lys 857 | - | expression tag |
Ala 858 | - | expression tag |
His 859 | - | expression tag |
His 860 | - | expression tag |
His 861 | - | expression tag |
His 862 | - | expression tag |
His 863 | - | expression tag |
His 864 | - | expression tag |
His 865 | - | expression tag |
His 866 | - | expression tag |
His 867 | - | expression tag |
His 868 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 394879.0 | |
Non-Polymers* | Number of molecules | 24 |
Total formula weight | 15918.2 | |
All* | Total formula weight | 410797.2 |