7LPA

Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 1	polymer	868	98719.8	4	UniProt (O35433) Pfam (PF00023) Pfam (PF00520) In PDB	Rattus norvegicus (Rat)	TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like
2	D, A, B, C	1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine	non-polymer		760.1	8	Chemie (LBN)
3	C, A, D, B	[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate	non-polymer		718.0	12	Chemie (6OU)
4	C, D, A, B	(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide	non-polymer		305.4	4	Chemie (4DY)
5	D, A, B, C	1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol	non-polymer		749.0	4	Chemie (YFP)
6	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)

Sequence modifications

A, B, C, D: 1 - 838 (UniProt: O35433)

PDB	External Database	Details
Glu 839	-	expression tag
Asn 840	-	expression tag
Ser 841	-	expression tag
Leu 842	-	expression tag
Glu 843	-	expression tag
Val 844	-	expression tag
Leu 845	-	expression tag
Phe 846	-	expression tag
Gln 847	-	expression tag
Gly 848	-	expression tag
Pro 849	-	expression tag
Asp 850	-	expression tag
Tyr 851	-	expression tag
Lys 852	-	expression tag
Asp 853	-	expression tag
Asp 854	-	expression tag
Asp 855	-	expression tag
Asp 856	-	expression tag
Lys 857	-	expression tag
Ala 858	-	expression tag
His 859	-	expression tag
His 860	-	expression tag
His 861	-	expression tag
His 862	-	expression tag
His 863	-	expression tag
His 864	-	expression tag
His 865	-	expression tag
His 866	-	expression tag
His 867	-	expression tag
His 868	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	394879.0
Non-Polymers*	Number of molecules	30
	Total formula weight	18960.2
All*	Total formula weight	413839.2

*Water molecules are not included.