7LOP

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (W, B)	CR3022 Fab heavy chain	polymer	222	23455.4	2		Homo sapiens
2	B, D (V, C)	CR3022 Fab light chain	polymer	221	24377.0	2		Homo sapiens
3	E, J (Z, A)	Spike protein S1	polymer	231	26095.3	2	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
4	F, H (X, H)	CV05-163 Fab heavy chain	polymer	227	24227.3	2		Homo sapiens
5	G, I (Y, L)	CV05-163 Fab light chain	polymer	216	23521.1	2		Homo sapiens
6	K, L (Z, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	M, N, O, P, Q... (W, V, B, C, Z...)	water	water		18.0	1237	Chemie (HOH)

Sequence modifications

Z, A: 319 - 541 (UniProt: P0DTC2)

PDB	External Database	Details
Ser 542	-	expression tag
Gly 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	243352.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	243794.7

*Water molecules are not included.